منابع مشابه
Genetic Regulation of Endothelial Vasomotor Function
The endothelium plays an important role in the regulation of vasomotor tone and the maintenance of vascular integrity. Endothelial dysfunction, i.e., impaired endothelial dependent dilation, is a fundamental component of the pathogenesis of cardiovascular disease. Although endothelial dysfunction is associated with a number of cardiovascular disease risk factors, those risk factors are not the ...
متن کاملTesting endothelial vasomotor function: nitric oxide, a multipotent molecule.
The initial description in 1980 by Furchgott and Zawadzki1 of endothelium-derived vasodilator factor has stimulated more than 2 decades of intense research to delineate the basic biology of the endothelium and its importance in the clinical setting.2 Endotheliumderived vasodilator factor has been identified as nitric oxide (NO).2 It is formed in endothelial cells from the amino acid L-arginine ...
متن کاملImpaired endothelial vasomotor function after sirolimus-eluting stent implantation.
BACKGROUND Sirolimus inhibits endothelial cell proliferation in vitro, but although the sirolimus-eluting stent (SES) is widely used because of the very low rates of in-stent restenosis, the influence of SES on coronary endothelial vasomotor function in humans is not well known. METHODS AND RESULTS The present study included 21 patients treated with SES, and 12 patients treated with conventio...
متن کاملPeripheral vasomotor function in cretinism.
These features of poor peripheral circulation which Lawson Wilkins (1950) emphasizes in his description of hypothyroidism in childhood are well-known physical signs and, as he says, are often of diagnostic value. They are usually included in a description of the bradycardia, hypotension and other signs of a slowly functioning cardiovascular system in textbook descriptions of the disease, and it...
متن کاملEndothelial cell signaling during conducted vasomotor responses.
ACh and KCl stimulate vasomotor responses that spread rapidly and bidirectionally along arteriole walls, most likely via spread of electric current or Ca2+ through gap junctions. We examined these possibilities with isolated, cannulated, and perfused hamster cheek pouch arterioles (50- to 80-microm resting diameter). After intraluminal loading of 2 microM fluo 3 to measure Ca2+ or 1 microM di-8...
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ژورنال
عنوان ژورنال: BMJ
سال: 2001
ISSN: 0959-8138
DOI: 10.1136/bmj.323.7309.352